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Thrombocytopenia due to immune destruction

MedGen UID:
75778
Concept ID:
C0272286
Disease or Syndrome
Synonym: Immune thrombocytopenia
SNOMED CT: Immune thrombocytopenia (2897005); ITP - immune thrombocytopenia (2897005); Thrombocytopenia due to immune destruction (2897005)
 
Monarch Initiative: MONDO:0002048

Definition

Thrombocytopenia that results from immune destruction of platelets. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThrombocytopenia due to immune destruction

Professional guidelines

PubMed

Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Kochhar M, Neunert C
Blood Rev 2021 Sep;49:100822. Epub 2021 Mar 8 doi: 10.1016/j.blre.2021.100822. PMID: 33736875
Terrell DR, Neunert CE, Cooper N, Heitink-Pollé KM, Kruse C, Imbach P, Kühne T, Ghanima W
Medicina (Kaunas) 2020 Nov 30;56(12) doi: 10.3390/medicina56120667. PMID: 33266286Free PMC Article

Recent clinical studies

Etiology

Liu XG, Hou Y, Hou M
J Hematol Oncol 2023 Jan 19;16(1):4. doi: 10.1186/s13045-023-01401-z. PMID: 36658588Free PMC Article
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Kochhar M, Neunert C
Blood Rev 2021 Sep;49:100822. Epub 2021 Mar 8 doi: 10.1016/j.blre.2021.100822. PMID: 33736875
Terrell DR, Neunert CE, Cooper N, Heitink-Pollé KM, Kruse C, Imbach P, Kühne T, Ghanima W
Medicina (Kaunas) 2020 Nov 30;56(12) doi: 10.3390/medicina56120667. PMID: 33266286Free PMC Article
Onisâi M, Vlădăreanu AM, Spînu A, Găman M, Bumbea H
Rom J Intern Med 2019 Dec 1;57(4):273-283. doi: 10.2478/rjim-2019-0014. PMID: 31199777

Diagnosis

Liu XG, Hou Y, Hou M
J Hematol Oncol 2023 Jan 19;16(1):4. doi: 10.1186/s13045-023-01401-z. PMID: 36658588Free PMC Article
Gafter-Gvili A
Eur J Intern Med 2023 Feb;108:18-24. Epub 2022 Nov 21 doi: 10.1016/j.ejim.2022.11.022. PMID: 36424271
Kochhar M, Neunert C
Blood Rev 2021 Sep;49:100822. Epub 2021 Mar 8 doi: 10.1016/j.blre.2021.100822. PMID: 33736875
Onisâi M, Vlădăreanu AM, Spînu A, Găman M, Bumbea H
Rom J Intern Med 2019 Dec 1;57(4):273-283. doi: 10.2478/rjim-2019-0014. PMID: 31199777
Smock KJ, Perkins SL
Int J Lab Hematol 2014 Jun;36(3):269-78. doi: 10.1111/ijlh.12214. PMID: 24750673

Therapy

Panch SR, Guo L, Vassallo R
Blood Rev 2023 Nov;62:101135. Epub 2023 Oct 2 doi: 10.1016/j.blre.2023.101135. PMID: 37805287
Gafter-Gvili A
Eur J Intern Med 2023 Feb;108:18-24. Epub 2022 Nov 21 doi: 10.1016/j.ejim.2022.11.022. PMID: 36424271
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Kuter DJ, Efraim M, Mayer J, Trněný M, McDonald V, Bird R, Regenbogen T, Garg M, Kaplan Z, Tzvetkov N, Choi PY, Jansen AJG, Kostal M, Baker R, Gumulec J, Lee EJ, Cunningham I, Goncalves I, Warner M, Boccia R, Gernsheimer T, Ghanima W, Bandman O, Burns R, Neale A, Thomas D, Arora P, Zheng B, Cooper N
N Engl J Med 2022 Apr 14;386(15):1421-1431. doi: 10.1056/NEJMoa2110297. PMID: 35417637
Bussel JB, Soff G, Balduzzi A, Cooper N, Lawrence T, Semple JW
Drug Des Devel Ther 2021;15:2243-2268. Epub 2021 May 26 doi: 10.2147/DDDT.S299591. PMID: 34079225Free PMC Article

Prognosis

Nokhostin F, Bakhshpour F, Pezeshki SMS, Khademi R, Saki N
Expert Rev Hematol 2023 Jul-Dec;16(10):731-742. Epub 2023 Sep 8 doi: 10.1080/17474086.2023.2255750. PMID: 37668243
Kochhar M, Neunert C
Blood Rev 2021 Sep;49:100822. Epub 2021 Mar 8 doi: 10.1016/j.blre.2021.100822. PMID: 33736875
Terrell DR, Neunert CE, Cooper N, Heitink-Pollé KM, Kruse C, Imbach P, Kühne T, Ghanima W
Medicina (Kaunas) 2020 Nov 30;56(12) doi: 10.3390/medicina56120667. PMID: 33266286Free PMC Article
Newland AC, Sánchez-González B, Rejtő L, Egyed M, Romanyuk N, Godar M, Verschueren K, Gandini D, Ulrichts P, Beauchamp J, Dreier T, Ward ES, Michel M, Liebman HA, de Haard H, Leupin N, Kuter DJ
Am J Hematol 2020 Feb;95(2):178-187. Epub 2019 Dec 10 doi: 10.1002/ajh.25680. PMID: 31821591Free PMC Article
Scaradavou A
Blood Rev 2002 Mar;16(1):73-6. doi: 10.1054/blre.2001.0188. PMID: 11914001

Clinical prediction guides

Rubenstein AI, Pierson SK, Shyamsundar S, Bustamante MS, Gonzalez MV, Milller ID, Brandstadter JD, Mumau MD, Fajgenbaum DC
Br J Haematol 2024 Mar;204(3):921-930. Epub 2024 Jan 2 doi: 10.1111/bjh.19279. PMID: 38168727Free PMC Article
Cooper N, Ghanima W, Vianelli N, Valcárcel D, Yavaşoğlu İ, Melikyan A, Ruiz EY, Haenig J, Somenzi O, Lee J, Clark J, Zhang Y, Zaja F
Am J Hematol 2024 Jan;99(1):57-67. Epub 2023 Nov 28 doi: 10.1002/ajh.27131. PMID: 38014779
Cheng J, Zeng H, Chen H, Fan L, Xu C, Huang H, Tang T, Li M
Front Immunol 2023;14:1213510. Epub 2023 Sep 28 doi: 10.3389/fimmu.2023.1213510. PMID: 37841241Free PMC Article
Yazdanbakhsh K, Provan D, Semple JW
Br J Haematol 2023 Oct;203(1):54-61. doi: 10.1111/bjh.19079. PMID: 37735552Free PMC Article
Newland A, Lee EJ, McDonald V, Bussel JB
Immunotherapy 2018 Jan;10(1):9-25. Epub 2017 Oct 2 doi: 10.2217/imt-2017-0097. PMID: 28967793

Recent systematic reviews

Walle M, Arkew M, Asmerom H, Tesfaye A, Getu F
PLoS One 2023;18(11):e0295011. Epub 2023 Nov 30 doi: 10.1371/journal.pone.0295011. PMID: 38033118Free PMC Article
Ibrahim L, Dong SX, O'Hearn K, Grimes AB, Kaicker S, FritchLilla S, Breakey VR, Grace RF, Lebensburger JD, Klaassen RJ, Lambert M
Pediatr Blood Cancer 2023 Mar;70(3):e30173. Epub 2022 Dec 29 doi: 10.1002/pbc.30173. PMID: 36579787
Jacobs JW, Booth GS
Am J Clin Pathol 2022 Jun 7;157(6):844-851. doi: 10.1093/ajcp/aqab210. PMID: 34919640Free PMC Article
Sandvad M, Pedersen EA, Frederiksen H, Mannering N
Expert Rev Hematol 2021 Oct;14(10):961-974. Epub 2021 Sep 16 doi: 10.1080/17474086.2021.1976635. PMID: 34487679
Wang L, Gao Z, Chen XP, Zhang HY, Yang N, Wang FY, Guan LX, Gu ZY, Zhao SS, Luo L, Wei HP, Gao CJ
Sci Rep 2016 Dec 19;6:39003. doi: 10.1038/srep39003. PMID: 27991534Free PMC Article

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